Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

This work has been supported by the Medical Research Council UK (Project Grant MR/K020455/1, LAM) and the Wellcome Trust (Clinical Research Training Fellowship Grant WT095984AIA, RP). LG is funded by the Biotechnology and Biological Sciences Research Council (BB/L002671/1) and the Rosetrees Trust. The human embryonic and fetal material was provided by the Joint MRC/Wellcome Trust (grant no. 099175/Z/12/Z) HDBR; JCA is a Wellcome Trust Senior Research Fellow in Clinical Science (grant no. 098513/Z/12/Z) with support from the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children (GOSH) NHS Foundation Trust and University College London. GOSgene is supported by the National Institute for Health Research Biomedical Research Centre (NIHR BRC) at the GOSH NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health. See Supplemental Acknowledgments for center details.