A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis.
2005
This investigation was an extension of a previous
study conducted in our laboratory in which we showed that 1
month of treatment with a topical cream (Celadrint) consisting
of cetylated fatty acids was effective for reducing pain and improving
functional performance in individuals with osteoarthritis
(OA) of the knee (Kraemer et al., Journal of Rheumatology,
2004). We wanted to verify that the addition of menthol to the
compound would produce a similar percentage of improvement
in therapeutic effects. We used a single treatment group with a
pre-post experimental design to examine % treatment changes.
Individuals diagnosed with OA of the knee (N = 10; age, 66.4 ±
11.5 years) and severe pain (e.g., OA, rheumatoid arthritis) of
the elbow (N = 8; age, 59.1 ± 18.2 years) and wrist (N =10;
age, 60.3 ± 16.8 years) were tested for pain and functional performance
before and after 1 week of treatment with a topical
cream consisting of cetylated fatty acids and menthol applied
twice per day. In individuals with knee OA, significant improvements
in stair-climbing ability (about 12%), ��up-and-go�� performance
(about 12%), balance and strength (about 16.5%), and
range of motion (about 3.5%) were observed, as were reductions
in pain. In individuals with severe pain of the elbow and wrist,
significant improvements in dynamic (about 22 and 24.5%, respectively)
and isometric (about 33 and 42%, respectively) local
muscular endurance were observed, as was a reduction in pain.
Neither group demonstrated significant changes in maximal
grip strength or maximal force production. One week of treatment
with a topical cream consisting of cetylated fatty acids and
menthol was similarly effective for reducing pain and improving
functional performance in individuals with arthritis of the knee,
elbow, and wrist. The % changes were consistent with our prior
work on the compound without menthol. Further work is needed
to determine the impact of menthol in such a cream. Nevertheless,
our data support the use of a topical cream consisting of
cetylated fatty acids (with or without menthol) for enhancing the
potential for exercise training in this population.
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