Physicochemical and Pharmacokinetic Evaluation of Spray-Dried Coformulation of Salvia miltiorrhiza Polyphenolic Acid and L-Leucine with Improved Bioavailability

Peng Lu,Yue Xing,Hui Peng,Zhidong Liu,Qi Tony Zhou,Zhifeng Xue,Zhe Ma,Dereje Kebebe,Bing Zhang,Hongfei Liu

Physicochemical and Pharmacokinetic Evaluation of Spray-Dried Coformulation of Salvia miltiorrhiza Polyphenolic Acid and L-Leucine with Improved Bioavailability

2019

Peng Lu
Yue Xing
Hui Peng
Zhidong Liu
Qi Tony Zhou
Zhifeng Xue
Zhe Ma
Dereje Kebebe
Bing Zhang
Hongfei Liu

Abstract Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is...

Keywords:

Anesthesia
Salvia miltiorrhiza
Medicine
Bioavailability
Traditional medicine
Polyphenol
Leucine
Pharmacokinetics
spray dried
dry powder inhalation
in vitro cytotoxicity

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