Prevalence of Polycystic Ovary Syndrome in Patients With McCune Albright Syndrome

ABSTRACT Study Objective To identify polycystic ovarian syndrome (PCOS) in a population of female patients with McCune−Albright syndrome (MAS) by retrospective chart review. Design Retrospective study. Setting Academic setting. Participants All female patients with a prior diagnosis of MAS who were more than 12 years of age at the time of chart review. Only complete medical records from January 2009 to January 2020 were included in the analysis. Interventions None. Main Outcome Measure(s) Diagnosis of PCOS based on the Rotterdam 2003 criteria. Results Seventeen female patients with MAS were included in the analysis. PCOS appeared to be more prevalent in MAS patients than expected based on population estimates (exact binomial test = 0.353; CI = 0.142-0.617, P = .01). The average body mass index was not significantly different between MAS patients with and without PCOS (23.38 kg/m2 vs 23.44 kg/m2, 2-sample Wilcoxon rank-sum test with continuity correction, W = 29, P = 0.733). The majority of patients (71%) were treated with an aromatase inhibitor and/or a gonadotropin-releasing hormone (GnRH) agonist. Conclusions The results of this study suggest that female individuals with MAS have a statistically higher prevalence of PCOS. These findings warrant further studies to determine whether the increased risk of PCOS may be associated with precocious puberty, treatment of precocious puberty, or other factors.