Antibiotic A-16316-C, a new water-soluble basic antibiotic.

A new water-soluble basic antibiotic named antibiotic A-16316-C was isolated together with antibiotic A-396-I and hygromycin B from a streptomyces strain identified as Streptoverticillium eurocidicus. The properties of the antibiotic A-16316-C were similar to those of destomycin B. But, it was found that the antibiotic A-16316-C was not identical with destomycin B on the basis of NMR analysis. On acidic degradation antibiotic A-16316-C gave N, N'-dimethyl-2-deoxystreptamine, destomic acid and D-mannose. The gross structure for antibiotic A-16316-C was deduced from chemical reactions and spectral data.