Novel EGFL7-FOSB fusion in Pseudomyogenic Hemangioendothelioma with Widely Metastatic Disease.

Pseudomyogenic hemangioendothelioma (PHE) is a rare vascular neoplasm with intermediate malignant potential first described by Mirra et al. in 1992. Young males are most commonly effected, with the distal extremities the most likely site of disease. Metastases are extremely uncommon, and widely metastatic disease present at initial diagnosis even less so. These tumors are associated with FOSB gene fusions. We present an unusual case of PHE with widely metastatic disease at presentation, along with novel EGFL7-FOSB gene fusion.