Aggressive B-cell lymphomas. Recommendations from the German Panel of Reference Pathologists in the Competence Network onMalignant Lymphomas on diagnostic procedures according to the currentWHO classification, update 2017

: The update of the 4th edition of the WHO classification for hematopoietic neoplasms introduces changes in the field of mature aggressive B‑cell lymphomas that are relevant to diagnostic pathologists. In daily practice, the question arises of which analysis should be performed when diagnosing the most common lymphoma entity, diffuse large B‑cell lymphoma. We discuss the importance of the cell of origin, the analysis of MYC translocations, and the delineation of the new WHO entities of high-grade B‑cell lymphomas.