Recent advances in transition metal (Pd, Ni)-catalyzed C(sp3)H bond activation with bidentate directing groups

Abstract In recent years, transition metal-catalyzed C(sp 3 ) H functionalization has gradually emerged as a practical and powerful tool to prepare highly valuable chemicals. In this mini-review, we will give some examples to cover recent research advances on transition-metal (Pd, Ni) catalyzed C(sp 3 ) H functionalization via bidentate directing group coordination. Different bidentate directing groups will be discussed. As the whole field of transition metal-catalyzed C(sp 3 ) H functionalization keeps moving forward, more synthetically useful chemo-, regio-, diastereo-, and enantioselective reactions catalyzed by transition-metal with bidentate directing group coordination will be discovered in the future and this promising and attractive strategy will play a more critical role in modern organic synthesis.