Influenza and dengue virus co‐infection impairs monocyte recruitment to the lung, increases dengue virus titers, and exacerbates pneumonia

Single infection with pandemic influenza (H1N1) or dengue virus (DENV) induces mild airway inflammation and mild disease. In contrast, co‐infected mice (H1N1–DENV) develop lethal disease that is characterized by lack of monocyte recruitment to the lung, truncated immune responses, severe pneumonia, and systemically increased dengue virus titers.