Production of a polyglobulin preparation against respiratory diseases in calves

: On the basis of literature data concerning the production of polyglobulins from animal sera with the employment of appropriate, short term methods, and using the author's personal experience a method was tested for the production of specific polyglobulins against the respiratory complex in calves. A particular scheme was used for the purpose, hyperimmunizing adult cattle with killed vaccines against parainfluenza-3, adenoviruses 1 and 3, and IBR. The hyperimmune serum obtained was further treated by the etanol short term method to produce a high-titer polyglobulin. The preparation was tested in the field in the control of respiratory diseases in calves, showing very good prophylactic effects with an abrupt drop of the morbidity rate. In the case of disease outbreaks among treated animals these responded positively to an effective causal therapy. Thanks to its usability the method is recommended for the practice.