Lipopolysaccharide enhances glutaric acid-induced seizure susceptibility in rat pups: Behavioral and electroencephalographic approach

Summary Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures. Considering that seizures are precipitated by common infections in children with GA-I, we investigated whether lipopolysaccharide (LPS) modifies GA-induced electrographic and neurochemical alterations in 21 days-old rats. The effect of LPS on convulsive behavior and electroencephalographic (EEG) alterations induced by GA (0.13; 0.4; 1.3mol/striatum) was determined in freely moving rats. After EEG recordings, we measured the levels of interleukin 1 (IL-1) in GA-injected striatum. The injection of LPS (2 mg/kg; i.p.) 6 h before of GA administration, reduced the latency and increased the