Calibration phantom for the quantification of fluorescent labels in deep skin tissue
2011
A method to quantify fluorescent labels spatially resolved in scattering and
absorbing samples is proposed and tested using a tissue phantom. The method works
without any a priori knowledge about the optical properties of the sample. The
scattering and absorption behavior of the sample is estimated by measuring
reflectance from the sample simultaneously to the fluorescence. With this
estimation, the attenuation of the fluorescence caused by scattering and absorption
can be mathematically compensated. The method is planned to be used for evaluating
skin penetrating drug carrier systems.
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