Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin

Direct evidence that augmentation of the late Na+ current can lead to an increase of the intracellular Na+ concentration ([Na+]i) in rabbit cardiomyocytes was obtained. The contribution of prolongation of action potential to anemone toxin-induced [Na+]i accumulation was estimated. Correlation between [Na+]i and diastolic Ca2+ concentrations in cytosol was established