Ekspresja wybranych białek jąderkowych w limfocytach przewlekłej białaczki limfocytowej Expression of selected nuclear proteins in the lymphocytes of Chronic Lymphocytic Leukemia

Summary Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia among adult. CLL is an heterogeneous disease with a variable clinical course. Same patients start with an asymptomatic indolent disease that may or may not progress over their lifetime. Others present with an aggressive disease, requiring therapy soon after diagnosis. Consequently, considerable effort has focused on understanding of molecular and clinical characteristics that are likely to predict the course of CLL. This paper attempts to present the role of selected nuclear proteins: nucleolin, nucleophosmin and fibrillarin, which play essential role in ribosome biogenesis in Chronic Lymphocytic Leukemia.