Comparison of the effects of penehyclidine hydrochloride and anisodamine in the treatment of renal colic

Objective To compare the clinic effects of penehyclidine hydrochloride and anisodamine(654-2) in the treatment of renal colic. Methods In this study, 399 patients with emergency renal angina were enrolled, and they were randomly divided into treatment group(199 cases) and control group (200 cases). The treatment group was treated by penehyclidine hydrochloride, while the control group was treated by 654-2.Before and after the treatment, all patients were marked by score. Results The remission rates of the treatment group at 10min, 15min, 20min, 30min were all higher than those of the control group (33.67% vs.18.50%, 53.77% vs.31.00%, 61.31% vs.50.00%, 85.43% vs.%75.50, χ2=11.91, 21.18, 8.40, 6.25, all P<0.05). The adverse effect rates of red face, dry mouth and heart rate increasing in the treatment group were lower than those in the control group(32.66% vs.50.00%, 39.20% vs.55.50%, 0.00% vs.19.50%, χ2=12.36, 10.63, 43.00, all P<0.05). Conclusion The penehyclidine hydrochloride has better effect, and with less side effect. Key words: Renal colic; Analgesia; Penehyclidine hydrochloride; Anisodamine