NGAL como predictor temprano de función retardada del injerto renal

Introduction: Delayed graft function (DGF) presents in about 20 to 50 percent of kidney transplants. Objective: To describe the role of urinary lipocain associated to neutrophil gelatinase (NGALu) in kidney transplanted recipients with deceased donor and compare it to the percentage of decrease of creatinine (PdC) to early detection fo DGF. Materials and methods: Prospective cohort in which NGALu levels were evaluated in the first, 12 , 24 and 48 hours after kidney transplant, comparing it daily to PdC until the 5th day. Results: 79 kidney transplanted patients with deceased donors were included in the study, DGF presented in 13 patients (16.5%) and 5 (6.3%) required dialysis in the first week. NGALu levels at all the cut-off points were higher in patients with DGF (p=0,526, p=0,049, p=0,032 and p=0,001 respectively). NGALu level > 109mg/ml at 48 hours predicted DGF with a sensitivity of  75% and specificity of 71%; the PdC level hat better predicted DGF was at 48 hours con un valor of 59.5% with a sensitivity of 92% and a specificity of 83Using a logistic regression for the adjusted DGF the only significant values to predict DGF were NGALu and PdC, being more accurate the PdC value. Conclusions: NGALu levels measured at 48 hours after renal transplantation predict DGF, including the need for dialysis; however, this marker was not superior to the CRR for early detection.