Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
2014
Parkinson’s disease can be caused by a rare mutation in the protein VPS35, but the mechanism responsible for this is largely unknown. Here, Zavodszky et al. show that this mutation leads to defects in the recruitment of endosomal protein sorting machinery and consequent inhibition of autophagy in cells.
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