2,4-Di (phenylamino) pyrimidines useful for the treatment of neoplastic diseases and inflammatory disorders and immune system

It compound of formula I ** ** Formula each of R0 or R2 independently is hydrogen, C1-C8 alkyl, C1-C8 alkyl, or halogen; R1 is hydrogen, C1-C8, C1-C8, 5- or 6-membered unsubstituted or substituted quecomprende 1 or 2 heteroatoms selected from N, O and S, C1-C8 alkoxy 20, or halogen; R3 is C1-C8-alkylsulfonyl, aryl C5-C10 alkylsulfonyl, substituted or unsubstituted carbamoyl, sulfamoyl or unsubstituted O-; or adjacent substituents R2 and R3 are -CH2-NH-CO-, -CH2-NH-SO2-, -CH2-CH2-SO2-, and those couples Lasque hydrogen in NH is replaced by C1-C8alkyl; R4 is hydrogen; R5 is chloro or bromo; R6 is hydrogen; each of R7 and R9 is independently hydrogen, C1-C8, C1-C8alkyl, C5-C10aryl unsubstituted O-, 5- or 6-membered unsubstituted or substituted comprising 1 or 2 heteroatoms selected from N, O and S , C1-C8 alkoxy, heterocyclyloxy unsubstituted or substituted C1-C8 nosustituido heterocyclylalkoxy or substituted amino unsubstituted or substituted, halogen, carbamoyl unsubstituted or substituted, or unsubstituted or substituted sulfamoilono; R8 is hydrogen, C1-C8alkyl, C1-C8alkyl, C5-C10aryl, 5- or 6-membered unsubstituted O- comprising 1 or 2 heteroatoms selected from N, O and S, C1-C8 haloalkoxy, C1- C8-C10-aryl C5 alkenyloxy, heterocyclyloxy unsubstituted or substituted heterocyclylalkoxy C1-C8 unsubstituted or substituted amino sustituidoo not substituted, halogen, sulfamoyl unsubstituted or substituted, or nitro; and R10 is C1-C8, C1-C8, C1-C8 alkoxy, or halogen; or each pair of adjacent substituents R7 and R8, or R8 and R9 or R9 and R10 is -NH-CH> = CH-, -CH> = CH-NH-, -NHN> = CH-, -CH> = N -NH-, -CH2-CH2-CH2-, -CH2-CH2-CH2-CH2-, -O-CH2-O- or -O-CF2-O-.