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Synthesis of 2[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-yl)propyl]-4- [4-tetrafluoropropoxyphenyl]-3-(2H,4H)-1,2,4-triazol-3-thione - A Novel and Potent Azole Antifungal Agent.
2010
Starting from the known epoxy alcohol (I), a new strategy for the synthesis of the potent fungicide (IX) in multigram quantities is developed.
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KQI