Cytogenetic analysis in acute leukemia

: Leukemic cells often show clonal cytogenetic abnormalities. Some of these are strongly associated with certain morphological subgroups and seem to be of prognostic importance. Cytogenetic studies and molecular genetic investigations using recombinant DNA technology have contributed to our understanding of the development of leukemia. This article reviews earlier work on cytogenetic findings in acute leukemia, and adds our own experiences.