Incohérence entre deux méthodes de dosage des D-dimères : un cas d'interférence d'anticorps humain anti-souris Discrepancy between two methods of D-dimers measurement: one case of human anti-mouse antibody interference

Quantification of D-dimers is the major biometry step in the dia- gnostic of an episode of the venous thromboembolic disease. The measurement of D-dimers can be performed with ELISA or immunoturbidimetric methods suited to emergency, using a mouse monoclonal antibody as capture and/or revelation antibody. Therefore, the presence in patient's plasma of human antibody mouse (HAMA) that binds the mouse antiglobulin used in immunoas- says can lead to false negative or false positive results. In a young woman presenting repetitive thoracic pain suggestive of a pulmonary embolism, a major discrepancy was found between one result of D-dimers above the cut-off with an immunoturbidimetric method (STA Liatest D-DI ® ; Diagnostica Stago) and one result below the cut-off with a sandwich method (Vidas D- abc