Liposomal Doxorubicin Increases Radiofrequency Ablation–induced Tumor Destruction by Increasing Cellular Oxidative and Nitrative Stress and Accelerating Apoptotic Pathways

Our study implicated the role of cellular stress through the production of oxidative and nitrative lipid, DNA, and protein damage followed closely by accelerated and increased apoptosis as a key mechanism for the synergistic effects of radiofrequency ablation and liposomal doxorubicin.