Unusual neurological manifestations of primary human immunodeficiency virus infection

The nervous system may be involved during primary human immunodeficiency virus (HIV) infection. Recognized clinical syndromes include meningitis, meningo-encephalitis, myelopathy, polyneuropathy and rhabdomyolysis. We report three patients with unusual neurological presentations of primary HIV infection: intracranial hypertension, severe encephalopathy characterized by personality changes and regressive behavior, and iumbosacral radiculoneuropathy. In all, the neurological disorder had a benign course and resolved within a few months. Awareness of the large spectrum of neurological manifestations of primary HIV infection can enable early diagnosis and treatment.