Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma

Background: The aim of this study was beer character- ize the staining paerns of inverted papilloma (IP) with and without carcinoma by performing immunohistochemistry for p16, epidermal growth factor receptor (EGFR), p53, and cyclin D1 antibodies in a large patient cohort. in 50%, p53 in 30%, and cyclin D1 in 76%. IP with carcinoma- tous degeneration was positive for p16 in 14%, EGFR in 71%, p53 in 62%, and cyclin D1 in 76%. The differences in staining positivity between benign and malignant disease reached significance for p16 and p53 only. Mean percentage staining by tumor surface area for IP and IP with carcinoma was 12% vs 7% for p16 (no statistical significance (NS)), 20% vs 34% for EGFR (NS), 4% vs 24% for p53 (p < 0.001), and 17% vs 21% for cyclin D1 (NS). Conclusion: Important characteristic staining paern for IP with and without carcinoma are highlighted in this study. Unlike recent trends in human papilloma virus (HPV)- related head and neck malignancies, low expression of p16 is a marker for malignancy in this series. Positive stain- ing for p53 correlates with the development of carcinoma in IP. C � 2013 ARS-AAOA, LLC.