[The covalent binding of a potent beta-receptor blocker (B 24/76) on tissue proteins and collagen in the rat].
1991
: Toxic effects of drugs and their metabolism may be caused by covalent binding to cellular macromolecules. After oral application of the tritiated beta-blocker B 24/76 to male Wistar rats only the liver showed a significant irreversible binding to tissue proteins, with 11% of the radioactivity distributed in this organ. A covalent binding to collagen was found in liver, lung and muscle. The highest part was measured in the lung with 7% of the radioactivity distributed in this organ.
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