Clinical course, biomarkers, management and outcomes of patients hospitalised due to COVID-19 in Colombia

Objective: To analyse the clinic characteristics, risk factors and evolution of the first cohort of hospitalised patients with confirmed infection by COVID-19 in 5 Colombian institutions Materials and methods: Is a retrospective observational study of consecutive hospitalized patients with a diagnosis of COVID-19 confirmed from March 01 to May 30, 2020 in Colombia Results: A total of 44 patients were included The median age was 62 years 43 2% had a history of smoking, while 69 8% were overweight or obese 88 6% had at least one comorbidity and 52 3% had three or more comorbidities Hypertension and dyslipidaemia were the most frequent comorbidities (40 9% and 34 1%, respectively) The 30-day mortality rate was 47 7% with a median of 11 days The composite outcome occurred in the 36 4% The biomarkers associated with mortality risk included troponin higher than 14 ng/L (RR: 5 25;95% CI 1 37-20 1, p = 0 004) and D-dimer higher than 1000 ng/ml (RR: 3 0;95% CI 1 4-6 3, p = 0 008) Conclusions: The clinical course of SARS-CoV-2 infection in hospitalized Colombian was characterised by a more advanced stage of the infection © 2021 Asociacion Colombiana de Infectologia All rights reserved