Роль интерлейкина-10 и влияние полиморфизма гена, который его кодирует, в течении инфекций, вызванных вирусом varicella-zoster

The purpose is to find out the role of changes in the quantitative content of IL-10 in association with the polymorphism of gene encoding it (rs 1800872) in the course of chickenpox and herpes zoster. Materials and methods. The study included 50 adult patients with chicken pox and 50 patients with herpes zoster. The analysis of the quantitative serum content of IL-10 depending on the genetic polymorphism of this cytokine (rs 1800872) and the effect on the disease course was carried out. The quantitative serum content of IL-10 was determined by enzyme immunoassay, the determination of single nucleotide polymorphism of IL-10 (rs 1800872) in whole venous blood of patients was performed by real-time polymerase chain reaction. The control group consisted of 40 healthy individuals. Statistical data processing was performed using the existing patient database with the application of Statistica for Windows 13 program (StatSoft Inc., No JPZ804I382130ARCN10-J). Results. The TT genotype of the IL-10 gene (rs 1800872) was found to be associated with severe varicella (P = 0.04) and herpes zoster (P = 0.01) in adults. In chickenpox patients, the TT genotype was associated with the development of hepatitis (χ 2 = 6.17, P = 0.01). In patients with herpes zoster, the TT genotype had an impact on the development of neurological (P = 0.03) and ophthalmic complications (P = 0.0001). Secondary bacterial complications were associated with the TG genotype of the IL-10 gene (rs 1800872) carrier state in all the patients (P < 0.05). It was proved that TT genotype was associated with an increase in serum IL-10 concentration (rs 1800872) in all the patients with infections caused by varicella-zoster virus on admission. In the course of the disease, the quantitative content of IL-10 decreased in all patients with the TT genotype, but remained elevated at the time of discharge (P < 0.05). In patients with chickenpox, the TG genotype carriage caused only an increasing trend in the serum IL-10 concentration not different from that in healthy individuals (P < 0.05). At the same time, in patients with herpes zoster, the TG genotype of the IL-10 gene (rs 1800872) was associated with an increased cytokine content both on admission and in the disease dynamics (P < 0.05). Conclusions. Changes in the serum concentration of IL-10 in patients with infections caused by varicella-zoster virus depend on the polymorphism of the IL-10 gene (rs 1800872) that encodes it, and are associated with certain clinical features of chickenpox and herpes zoster.