Clinicopathologic features and prognostic analyses of Borrmann type IV gastric cancer

Objective To compare Borrmann type Ⅳ gastric cancer with other types of cancer and explore their clinicopathological features and prognostic factors.Methods We retrospectively reviewed the medical records of 893 consecutive advanced gastric cancer patients. They were divided into 2 groups:Borrmann type Ⅳ ( n =139 ) and other macroscopic Borrmann types of cancer ( n =754 ).Their clinicopathologic characteristics and overall survival data were analyzed.Results Borrmann type Ⅳ gastric cancer was found to be associated with more advanced and unfavorable clinicopathological features. The incidence of preoperative biopsy-negative rate of Borrmann type Ⅳ gastric cancer was much higher ( 15.9％ )than other Borrmann types of gastric cancer.The 5-year survival rate of Borrmann type Ⅳ cancer patients was 9.9％ and it was significantly lower than that of other types.Moreover,the 5-year survival rate was higher in the patients with curative resection (18.7％) (P ＜ 0.05).Stratified analysis revealed that when the tumor TNM stages were of Ⅱ,Ⅲ,the survival data of Borrmann type Ⅳ cancer were worse than others.Multivariate analyses revealed distant metastasis and curability were independent prognostic factors for Borrmann type Ⅳ gastric cancer.Conclusions Borrmann type Ⅳ carcinoma has poor clinicopathological features and survival rate compared with other types. An early detection and curative resection may improve the prognosis for the patients with Borrmann type Ⅳ cancer. Key words: Stomach neoplasms; Pathology, clinical; Borrmann type Ⅳ; Prognosis