Effects of a single high-fat meal rich in cottonseed oil on lipid profile, insulin sensitivity, and multimeric forms of adiponectin of healthy females

This study investigates the effect of consuming a single high-fat meal rich in cotton seed oil (CSO) on plasma lipid, glucose, insulin, and adiponectin levels. In a randomized cross-over design, eleven healthy female subjects consumed 1 of 2 iso-caloric meals consisting of carrot muffin/s and milkshake providing 1 g of fat/kg body weight. Blended palm oil (BPO) served as control and blood drawn at baseline, 3 and 6 hours was analyzed for biochemical assays. One-way repeated ANOVA was performed followed by post-hoc tests to determine differences between three time periods and identify groups that were significantly different. Subjects were divided into groups based on the sequence of meal ingested (CSO followed by BPO) to account for carry-over effects. Consumption of CSO did not show any significant differences (p<0.05) in mean blood glucose levels compared to BPO controls. The serum insulin levels also did not reach significance. No significant differences were observed in plasma levels of total choleste...