Process for the preparation of sugar protein composition

The present invention, production of glycoprotein compositions using GDP- mannose GDP-4-keto, 6-deoxy -GDP- mannose into a reaction to introduce an RNA that suppresses the function of an enzyme that catalyzes cells and the cells method, N- glycoside-linked complex-type oligosaccharide reducing 1-position of fucose to 6-position of the end of the N- acetylglucosamine inhibit the function of an enzyme involved in sugar chain modification to bind alpha RNA, and an intracellular sugar nucleotide GDP- glycoprotein composition using cells and the cells were introduced that inhibits the function of RNA protein relating to transport of the enzyme protein that inhibits the function RNA or intracellular sugar nucleotide, GDP- fucose Golgi apparatus involved in the synthesis of fucose providing such manufacturing method of the object.