CoQ10 suppression of oxidative stress and cell senescence increases bone mass in orchiectomized mice.

Numerous studies support the detrimental effects of oxidative stress and cell senescence on skeletal homeostasis. Coenzyme Q10 (CoQ10) acts as a scavenger for oxidative stress and protects mitochondrial activity from oxidative damage. However, it is unclear whether CoQ10 has a protective effect on osteoporosis caused by orchiectomy. To investigate suppression effect of antioxidant CoQ10 on osteoporosis in orchiectomized (ORX) mice, ORX mice were supplemented with/without CoQ10, and were compared with each other and with sham-operated mice. Our results showed that CoQ10 could prevent ORX-induced bone loss by inhibiting oxidative stress and cell senescence, subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results of this study not only reveal the mechanism of CoQ10 supplementation in anti-osteoporosis, but also provide experimental and theoretical basis for the clinical application of CoQ10 in the prevention of osteoporosis.