Development of standardized therapeutic model in Korean type 2 diabetic patients

Background : There are few limitations in application of staged diabetes management (SDM) program to Korean type 2 diabetic patients because of their unique characteristics, such as non-obese but centrally obese anthropometry and variable relationships between insulin secretion and insulin resistance compared to western diabetic patients. Therefore, we proposed new therapeutic moded which considers ethnic characteristics and assesses patient by insulin secretion and insulin resistance. Methods : We have previously assessed patient's insulin secretion by serum fasting C-peptide level and insulin res:stance by insulin tolerance test (ITT) and porposed new cherapeutic model: by cut-off value of 2.5%/min in insulin resistance and 1.1 ng/dL. 1.7 ng/dL in insulin secretion. Results : Total 183 patients were enrolled In this program and 59% of total subjects had to change the treatrment modality according to this new therapeutic model. Mean fasting glucose level dropped from 177.038.6 mg/dL 9.832.14 mmol/L) to 148.231.2 mg/dL (8.231.73 mmol/L) (p60.1 mg/dL (14.193.34 mmol/L) to 221.158.4 mg/dL (12.273.24 mmol/L) (p1.42% to 7.721.39% (p