Dihydropyrimidine compounds and their use in medicine

The present invention relates to species-dihydro-pyrimidines and their use as medicament, in particular as a medicament for the treatment and prevention of hepatitis B. applications. More specifically, the present invention relates to formula (I) or (Ia) or a compound represented of the enantiomers, diastereomers thereof, tautomers, hydrates, solvates or pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification. The present invention further relates to compounds of formula (I) or (Ia) as shown, or to the enantiomers, diastereomers thereof, tautomers, hydrates, solvates or pharmaceutically acceptable salt thereof as a medicament, in particular as a medicament for the treatment and prevention of hepatitis B. purposes.