CORRESPONDENCE CASE REPORT Hypereosinophilic syndrome or chronic eosinophilic leukemia: report of a case with a lytic bone lesion

Some cases of hypereosinophilic syndrome and myeloprolifer- examination revealed hypercellular marrow with panhyperative disorders exhibit common features and thus pose diag- plasia which was predominantly myeloid. About half the grannostic and therapeutic problems. We describe a 68-year-old ulocytic cells were eosinophils and eosinophilic precursors. patient who presented with such features and developed lytic Trephine biopsy confirmed the nearly 100% marrow cellulesion in the tibia. Based on our case and a review of literature larity and moderately diffuse reticulin fibrosis. Cytogenetic we suggest that cases like ours should be classified and treated as chronic eosinophilic leukemia (a myeloproliferative studies on peripheral blood cells and bone marrow aspirate disorder) rather than as a hypereosinophilic syndrome or as an revealed a normal male karyotype with no evidence of Ph atypical chronic myeloid leukemia. chromosome. Bcr-abl rearrangement was not detectable by