Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(III) catalysis.
2021
The rhodium(III)-catalyzed spiroannulation reaction between N-aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.
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