牧丹皮의 效能主治에 대한 通時的 考察

To clearly analyze the pharmacological actions of Moutan Radicis Cortex (MRC), we carried out literature review. We selected major herbal books of Qin (秦), Han (漢), Tang (唐), Song (宋), Jin (金), Yuan (元), Ming (明) and Qing (淸) dynasty, and analyzed the efficacy and the main treatments. In Qin and Han Dynasty, MRC was used to disperse blood stasis without application of the deficiency (虛) and excess (實). In Tang-Song Dynasty, although the range of application was expanded but application of the deficiency (虛) and excess (實) was the same as previous dynasty. By the Jin-Yuan Dynasty, the deficiency and excess were applicated but its pharmacological actions was not cleary established. Widely recognized mechanism of MRC for removing pathogenic heat from the blood (凉血) and dispersing blood stasis (散瘀) nowadays was deeply discussed from the Ming Dynasty and established in the Qing Dynasty.