Influencing factors of epileptic seizure in patients with chronic renal failure

Objective To investigate the influencing factors of epileptic seizure in chronic renal failure (CRF) patients. Methods CRF patients, admitted to our hospital from March 2014 to October 2018, were chosen in our study, and divided into epilepsy group (n=40) and non-epilepsy group (n=3653) according to whether the patients were with or without epilepsy. Clinical data, as length of hospital stays, dialysis methods, presences of infection, sites of infection, and use of antibiotics, and laboratory variables, as blood routine examination, straw aminotransferase (AST), and alanine aminotransferase (ALT), were collected and retrospectively analyzed. Logistic regression analysis was used to determine the independent factors affecting seizures in patients with CRF. Results The patients in the epilepsy group had significantly longer duration of dialysis and length of hospital stays, statistically higher incidence of infection and proportion of dialysis, and significantly worse prognosis than the patients from non-epilepsy group (P<0.05). The leukocyte count of the epilepsy group was significantly higher than that of the non-epilepsy group, the contents of hemoglobin, ALT and albumin were significantly lower than those of the non-epilepsy group, and the contents of urea nitrogen, creatinine and serum potassium were significantly higher than those of the non-epilepsy group (P<0.05). Logistic regression analysis showed that epilepsy was associated with serum potassium, creatinine, urea nitrogen and dialysis. Conclusion The etiology of epilepsy is complex, which is related to dialysis, toxin levels, and electrolyte imbalance; the mortality rate of those patients is high and the prognosis is not good. Key words: Chronic renal failure; Epilepsy; Influencing factor