Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases: Opportunities and Challenges

As reported by Smyrnias et al. [(1)][1], pre-induction of mitochondrial unfolded protein response (UPRmt) using nicotinamide riboside is sufficient to prevent cardiac dysfunction induced by chronic hemodynamic overload in rodents. These findings open up a new avenue for strategies targeting