Physico-chemical and immunological properties of acid α-glucosidase from various human tissues in relation to glycogenosis type II (pompe's disease)

Abstract The physico-chemical and immunological properties of acid α-glucosidase from various human tissues have been studied. Heat stability of acid α-glucosidase from heart, liver and skeletal muscle is identical, but for kidney some different results are obtained. Identical isoelectrofocussing patterns are found for heart, liver and skeletal muscle. Furthermore, the effect of antiserum against human liver acid α-glucosidase on the activity of acid α-glucosidase from various tissues is studied. The results are discussed in relation to glycogenosis type II (Pompe's disease).