Endoscopic Full-Thickness Resection for Colorectal Neoplasm: Current Status and Future Directions

Purpose of Review Endoscopic submucosal dissection (ESD) is recognized as a minimally invasive treatment for colorectal cancer. However, colorectal ESD has not been internationally accepted as a first-line therapeutic option due to technical difficulties and high complication rates. Non-lifting tumors present a further limitation of ESD. Colorectal endoscopic full-thickness resection (eFTR) with over-the-scope clips (OTSCs) shows great potential in patients for whom ESD is not possible and also for those who might have ESD-related complications. The present manuscript aims to discuss the complementary role of eFTR using OTSCs and the future development of eFTR with a novel suturing device.