IDDF2020-ABS-0096 Clinical study on simplified endoscopic submucosal dissection for colorectal laterally spreading tumors

Background To evaluate the efficacy and safety of Simplified Endoscopic Submucosal Dissection (SESD) for colorectal laterally spreading tumors (LSTs). Methods Patients of colorectal laterally spreading tumors (LSTs) with a diameter of over 2 cm from January 2017 to January 2019 were enrolled in our study. Patients were assigned to 2 groups according to endoscopy procedures, the SESD group and ESD group.SESD includes three steps, 1) pre-cut circularly around the tumors, 2) dissected the connective tissue of the submucosa beneath the lesion,3) perform EMR to dissect the lesion when its diameter smaller than the endoloops. Clinical data of both groups, such as LST size, LST location, endoscopy procedures, procedure time, en bloc resection rate, and post-SESD complications, were retrospectively analyzed. Results 102 patients were involved in the study, SESD group involved 54 patients and ESD group involved 48 patients. The procedure time of SESD group was shorter than that of ESD group (P=0.32). There was no significant difference in the en bloc resection rate (SESD 100% vs.ESD 98%, P>0.05). Complication rates such as intraoperative perforation rate and postoperative bleeding rate also showed no statistic difference between two groups, so did recurrence rate. (P>0.05). Conclusions Simplified Endoscopic Submucosal Dissection was an effective and safe therapy for colorectal LSTs.