SAT0115 Correlations between Rheumatoid Arthritis Activity Indices and Factors Affecting Acute Phase Reactants in Patients with Rheumatoid Arthritis

Background Assessment of disease activity is a key part of clinical decision in rheumatology care. High disease activity presented by DAS28 >5.1 is used as a cutoff for biologic use in many countries include Korea, while remission (DAS28 Objectives We compared the DAS28ESR and DAS28CRP to other RA activity measures and were to find confounding factors affecting acute phase reactants to patients with rheumatoid arthritis to find best tool to access RA disease activity. Methods A cross-sectional study was conducted in 1120 patients with RA, using initial registration data from Korean Biologics Registry (KOBIO). Results In comparison of composite indices, DAS28CRP showed excellent correlation with SDAI (r =0.926, p In comparison of acute phase reactants to other disease activity measures, CRP showed low but significant correlation with SJC (r =0.132, p In correlation analysis using CDAI as controlled variable, ESR increased with age (r =0.110, p In the same analysis, CRP was not correlated with age, BMI, disease duration, RF and anti-CCP antibody. It was higher in male compared to female (3.41 ± 3.60 vs 2.42 ± 4.08 mg/dL, p=0.001) and higher in ever-smoker compared to never-smoker (3.23 ± 3.46 vs. 2.48 ± 4.10 mg/dL, p=0.027). There was no difference in CRP according to the presence of diabetes mellitus, obesity (BMI ≥30) or low body weight (BMI Conclusions Both DAS28CRP and DAS28ESR were well correlated with other activity indices and showed an excellent agreement in defining high disease activity. ESR increased with age but was less susceptible to gender or smoking status compared to CRP, suggesting DAS28ESR to be a more useful marker for inter-patient-comparison of RA disease activity. Disclosure of Interest None declared