Monoclonal Anti-B Cell Antibodies: their Effects on Human Mixed Lymphocyte Reactions

Abstract Three monoclonal antibodies which recognise determinants on the surface of human B cells have been studied for their effect on mixed lymphocyte reactions (MLR). MLR inhibition was observed under a variety of conditions. While it was not possible to ascribe lymphocyte activation to a single determinant recognised by any of the antibodies, further analysis of the mechanisms involved in lymphocyte activation should be possible through the use of monoclonal reagents.