Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight

The mechanisms by which maternal and fetal weight are regulated during pregnancy are poorly understood. The ob protein, termed leptin, is produced by adipocytes. It is involved in the regulation of body weight by suppressing appetite and stimulating energy expenditure both in humans and rodents. In this study we examined whether leptin concentrations in the mother and the newborn correlate with birth weight, placental weight, and maternal weight at term. Leptin concentrations were measured in amniotic fluid, venous and arterial cord blood, and maternal serum at birth (n = 27) using a specific RIA employing human recombinant leptin for tracer and standard preparation. Gestational age was 38–42 weeks, maternal age was 21–42 yr, mean maternal weight at birth was 80.0 ± 10.8 kg, and mean body mass index before pregnancy was 23.4 ± 2.8 kg/m2. The newborns’ mean weight was 3450 ± 580 g, and mean placental weight was 616 ± 120 g. Serum leptin levels from nonpregnant women ranged between 1.7–18.4 ng/mL, median 5....