The ultrastructural study of mucous membrane of eustachian tube in guinea pig with secretory otitis media treated by anbroxol

Objective To observe the ultrastructure of mucous membrane of eustachian tube in guinea pig with secretory otitis media treated by anbroxol with ultracytochemically.Methods Guinea pig with secretory otitis media were divided in two groups,anbroxol was injected into tympanum as therapeutic agent,physiological saline was used as control.The changes of ultrastructure of mucous membrane of eusta-chian tube in guinea pig with secretory otitis media were observed with electron microscope and light micro-scope.Results The pathologic changes were significantly different.After treated with anbroxol,pathologi-cal changes of cilium and microvilli in mucous membrane of eustachian tube were alleviated.Conclusion Application of anbmxol to treat guinea pig with secretory otitis media increased the surfactant-like lamellar bodies of mucous membrane of eustachian tube and recovered the structure quickly. Key words: Ambroxol/PD; Otitis Media with Effusion/DT/PA; Eustachian Tube/DE/UL