Synthesis of Analogues of the O‐β‐D‐Ribofuranosyl Nucleoside Moiety of Liposidomycins. Part 2. Role of the Hydroxyl Groups upon the Inhibition of MraY.

Abstract O -β- d -Ribofuranosyl nucleoside I is the minimal structural entity of liposidomycins that maintains enzyme inhibitory activity on MraY. A set of compounds with hydroxyl patterns different from I has been synthesized. The presence of a hydroxyl group in the 3″ position is essential for the activity. The 3′-deoxy derivative ( IV ), however, shows a 5-fold improved potency.