Quantifying development: Investigating highly myelinated voxels in preadolescent corpus callosum

Abstract Multi-echo T 2 relaxation decay data was acquired for 5 preadolescent males (age range 9–12 years). A signal to noise filter appropriate for multi-exponential T 2 analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated “highly myelinated” if their myelin water fraction (MWF) was greater than a critical value. We investigated a range of signal to noise filter cut-off values and highly myelinated critical values and demonstrated a significant correlation ( r  = 0.990, p