Metabolic and genetic aspects of the relationship between growth and tetracycline production in Streptomyces aureofaciens
1981
A mutant of S. aureofaciens characterized by lower growth and higher tetracycline production than its parent strain is described. The mutant has a limited degree of temperature-sensitivity and shows a lower efficiency in the utilization of phosphate for growth and a higher cellular content of RNA. The data are in accordance with a possible mutation impairing some aminoacyl RNA synthetases. This kind of mutation might explain the lower growth in phosphate limited conditions and the higher content of RNA.
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