A randomized double-blind study of fluoxetine versus placebo in the treatment of dysthymia.

Objectives: The purpose of this study was to assess the efficacy of fluoxetine, a selective serotonergic antidepressant, in the treatment of dysthymia, but not major depression, began randomized, double-blind 8-week trials of fluoxetine or placebo. Results: Of 32 patients who completed the study, 10 (62.5%) of the 16 patients given fluoxetine and three (18.8%) of the 16 given placebo responded to treatment