Mechanism of multiple organ dysfunction syndrome results from hemorrhagic hypovolemic shock

Objective To investigate the relationship between serum levels of TNF-α and IL-1 and prognosis of hemorrhagic hypovolemic shock. Methods The serum levels of TNF-α and IL-1 were measured by ELISA in 29 hemorrhagic hypovolemic shock patients, 20 patients for selective surgery served as a control group. The relationship between serum levels of TNF-α, IL-1 and MODS were analyzed. Results The morbidity rates of SIRS, MODS and infection in hemorrhagic hypovolemic shock group were significantly higher than those in control group (P0.05).The serum levels of TNF-α and IL-1 in hemorrhagic hypovolemic shock group were significantly higher than those in control group (P0.05). The serum levels of TNF-α in MODS group were significantly higher than that in non-MODS group (P0.05). In hemorrhagic hypovolemic shock group, the serum levels of TNF-α in the dieds were higher than those in survival patients (P0.05). Conclusion SIRS is a main cause of MODS and often occurred after hemorrhagic hypovolemic shock. The concentration of TNF-α in serum may be related closely with prognosis after hemorrhagic hypovolemic shock.